Human PDAC tumors shows co-expression of CXCL1 (red) and CK19 (green; a marker of PADC) by confocal microscopy. Credit: NYU Langone Medical Center
The most aggressive form of pancreatic cancer - often described as one of the hardest malignancies to diagnose and treat—thrives in the presence of neighboring tumor cells undergoing a particular form of "orchestrated cell death." This is according to a major study recently published in the journalNature.
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"Our findings are the first to show that cancer cell death via necroptosis can actually promote tumor growth, as this process results in suppression of the body's immune response against the cancer," said the study's senior investigator, George Miller, MD, associate professor in the Departments of Surgery and Cell Biology, and co-leader of the Cancer Immunology Program at the Perlmutter Cancer Center. "What is equally significant is that these findings might also be relevant to other tumor types."
Cell death mechanism may—paradoxically—enable aggressive pancreatic cells to live on
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